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Query: TUBB4A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TUBB4A 0 1.432 0.140 -0.670 -0.837 -0.149 0.035
TUBB4A 0 1.432 0.140 -0.670 -0.698 0.338 0.436

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TUBB4A Ubiquitylation K324 0.436 0.885 _MSMK(gl)EVDEQMLNVQNK_
TUBB4A Ubiquitylation K58 0.108 0.729 _INVYYNEATGGK(gl)YVPR_
TUBB4A Ubiquitylation K252 -0.665 -0.156 _K(gl)LAVNMVPFPR_

Background Information for TUBB4A:


Pubmed-TUBB4A »
Uniprot-TUBB4A »
Biogrid-TUBB4A »
ProteomicsDB-TUBB4A »

Tumorportal-TUBB4A »
COSMIC-TUBB4A »
GenomeRNAi-TUBB4A »
Genecards-TUBB4A


Protein-protein Interactions for TUBB4A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015


Protein Domains in TUBB4A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tubulin IPR000217 0
Category members Alpha_tubulin IPR002452 0
Category members Beta_tubulin IPR002453 0
Category members Gamma_tubulin IPR002454 0
Category members Delta_tubulin IPR002967 0
Category members Tubulin_FtsZ_GTPase IPR003008 0
Category members Epsilon_tubulin IPR004057 0
Category members Tub_FtsZ_C IPR008280 0
Category members Tubulin/FtsZ_2-layer-sand-dom IPR018316 0
Category members Misato_II_tubulin-like IPR019605 0


Protein complexes (CORUM database) featuring TUBB4A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TUBB4A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0051084 'de novo' posttranslational protein folding Database 0.63
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_1288 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC 0 0.4
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0007017 microtubule-based process Database 0.3
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_1296 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC 0 0.08
Category members Pathway Pathway_1295 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY 0 0.07
Category members GO Category GO:0051297 centrosome organization Database 0.04
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0033269 internode region of axon Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043209 myelin sheath Database 0
Category members GO Category GO:0051258 protein polymerization Database 0


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