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Query: TRPS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRPS1 0 2.092 -0.640 0.800 -0.396 -0.376 0.670 -0.130 -0.492

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRPS1 Phosphorylation S892 1.041 0.975 _RGS(ph)GVFCANCLTTK_
TRPS1 Phosphorylation T826 0.784 0.479 _T(ph)LRDSPNVEAAHLAR_
TRPS1 Phosphorylation S830 0.883 0.088 _TLRDS(ph)PNVEAAHLAR_
TRPS1 Phosphorylation S216 0.413 -0.372 _TDLLVNDNPDPAPLS(ph)PELQDFK_
TRPS1 Phosphorylation S178 0.790 _ATEETGQAQSGQANCQGLS(ph)PVSVASK_

Background Information for TRPS1:


Pubmed-TRPS1 »
Uniprot-TRPS1 »
Biogrid-TRPS1 »
ProteomicsDB-TRPS1 »

Tumorportal-TRPS1 »
COSMIC-TRPS1 »
GenomeRNAi-TRPS1 »
Genecards-TRPS1


Protein-protein Interactions for TRPS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK18 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRPS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92
Category members Znf_GATA IPR000679 0.29


Protein complexes (CORUM database) featuring TRPS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TRPS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006607 NLS-bearing protein import into nucleus Database 1.48
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Disease phenotype Langer-Giedion_syndrome Langer-Giedion syndrome Database 0
Category members Disease phenotype tricho-rhino-phalangeal_syndrome_type_2_(TRPS2) tricho-rhino-phalangeal syndrome type 2 (TRPS2) Database 0
Category members Disease phenotype TRICHORHINOPHALANGEAL_SYNDROME_TYPE_II TRICHORHINOPHALANGEAL SYNDROME TYPE II Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0031063 regulation of histone deacetylation Database 0
Category members GO Category GO:0032330 regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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