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Query: TNPO1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TNPO1 0 1.034 1.240 -0.920 -0.120 0.288 -0.034 0.255 -0.126

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TNPO1 Ubiquitylation K81 0.303 0.468 _SLSGLILK(gl)NNVK_
TNPO1 Ubiquitylation K66 0.261 _LK(gl)SEDEPTR_

Background Information for TNPO1:


Pubmed-TNPO1 »
Uniprot-TNPO1 »
Biogrid-TNPO1 »
ProteomicsDB-TNPO1 »

Tumorportal-TNPO1 »
COSMIC-TNPO1 »
GenomeRNAi-TNPO1 »
Genecards-TNPO1


Protein-protein Interactions for TNPO1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP7A Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf9;SUCO Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERBB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUSC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TNPO1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83
Category members Importin-beta_N IPR001494 0


Protein complexes (CORUM database) featuring TNPO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TNPO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members GO Category GO:0000060 protein import into nucleus, translocation Database 0.42
Category members GO Category GO:0008536 Ran GTPase binding Database 0.21
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0008139 nuclear localization sequence binding Database 0


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