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Query: TLE3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TLE3 0 -0.315 0.500 -0.730 -0.204 -0.609
TLE3 0 -0.315 0.500 -0.730 -1.130

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TLE3 Phosphorylation S213 0.308 0.467 _ESSANNSVS(ph)PSESLR_
TLE3 Phosphorylation S296 -0.181 -0.019 _DAPTS(ph)PASVASSSST(ph)PSSK_
TLE3 Phosphorylation T295 -0.221 -0.058 _DAPT(ph)SPASVASSSSTPSSK_
TLE3 Ubiquitylation K230 -0.057 -0.119 _GSADYSMEAK(gl)KR_
TLE3 Ubiquitylation K231 -0.160 -0.119 _GSADYSMEAKK(gl)_
TLE3 Phosphorylation T344 -1.034 -0.386 _NDAPTPGTSTT(ph)PGLR_
TLE3 Phosphorylation T306 -0.680 -0.965 _DAPTS(ph)PASVASSSST(ph)PSSK_
TLE3 Phosphorylation S305 -0.995 _DAPTS(ph)PASVASSSS(ph)TPSSK_
TLE3 Phosphorylation T338 -1.514 -1.552 _NDAPT(ph)PGTSTT(ph)PGLR_
TLE3 Phosphorylation T341 -1.951 _NDAPT(ph)PGT(ph)STTPGLR_
TLE3 Ubiquitylation K314 -0.038 _DLGHNDK(gl)SSTPGLK_
TLE3 Ubiquitylation K321 -0.502 _SSTPGLK(gl)SNTPTPR_
TLE3 Ubiquitylation K348 -1.596 _SMPGK(gl)PPGMDPIASALR_
TLE3 Ubiquitylation K508 0.853 _HVYTGGK(gl)GCVK_
TLE3 Ubiquitylation K522 -0.788 _IWDISQPGSK(gl)SPISQLDCLNR_

Background Information for TLE3:





Protein-protein Interactions for TLE3

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HLX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STARD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBX20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VENTX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TLE3

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Groucho/TLE_N IPR005617 0
Category members Groucho_enhance IPR009146 0


Protein complexes (CORUM database) featuring TLE3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3149 NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex Database 0.04
Category members Corum 3127 TLE-Histone H3 complex Database 0
Category members Corum 3150 NK-3-Groucho complex Database 0


Categories featuring TLE3

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0


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