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Query: TKT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TKT 1 3.327 0.500 -0.610

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TKT Ubiquitylation K319 1.271 1.560 _K(gl)AYGQALAK_
TKT Ubiquitylation K310 0.188 1.179 _MPSLPSYK(gl)VGDK_
TKT Ubiquitylation K16 -0.080 1.078 _LQALK(gl)DTANR_
TKT Ubiquitylation K6 0.465 0.423 _(ac)MESYHK(gl)PDQQK_
TKT Ubiquitylation K597 -0.077 0.231 _SGK(gl)PAELLK_
TKT Ubiquitylation K353 0.209 _NSTFSEIFKK(gl)_
TKT Ubiquitylation K232 -0.004 -0.192 _AFGQAK(gl)HQPTAIIAK_
TKT Ubiquitylation K204 -0.765 -0.280 _LGQSDPAPLQHQMDIYQK(gl)R_
TKT Phosphorylation T295 0.496 _ILAT(ph)PPQEDAPSVDIANIR_
TKT Ubiquitylation K538 -1.355 _VLDPFTIK(gl)PLDR_

Background Information for TKT:


Pubmed-TKT »
Uniprot-TKT »
Biogrid-TKT »
ProteomicsDB-TKT »

Tumorportal-TKT »
COSMIC-TKT »
GenomeRNAi-TKT »
Genecards-TKT


Protein-protein Interactions for TKT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXOSC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCD Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATG2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DMWD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GOLGA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TKT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBA4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TKT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DH_E1 IPR001017 0.19
Category members THDP-binding IPR029061 0.04
Category members Transketolase-like_Pyr-bd IPR005475 0.01
Category members Transketolase_N IPR005474 0
Category members Transketolase_C IPR005476 0
Category members Transketo_C/Pyr-ferredox_oxred IPR009014 0


Protein complexes (CORUM database) featuring TKT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TKT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members GO Category GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Database 0.19
Category members Pathway Pathway_51 KEGG_PENTOSE_PHOSPHATE_PATHWAY 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0006098 pentose-phosphate shunt Database 0.07
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0004802 transketolase activity Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0005999 xylulose biosynthetic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009052 pentose-phosphate shunt, non-oxidative branch Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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