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Query: TERF2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TERF2 2 3.592 -0.890 1.220 1.701 2.316 -0.080 0.502

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TERF2 Phosphorylation S323 -1.051 -1.345 _DLVLPTQALPAS(ph)PALK_
TERF2 Ubiquitylation K307 0.329 _TLSGAQDSEAAFAK(gl)LDQK_

Background Information for TERF2:


Pubmed-TERF2 »
Uniprot-TERF2 »
Biogrid-TERF2 »
ProteomicsDB-TERF2 »

Tumorportal-TERF2 »
COSMIC-TERF2 »
GenomeRNAi-TERF2 »
Genecards-TERF2


Protein-protein Interactions for TERF2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait POT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF2IP Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARL4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARL4D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC106 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX39A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGFRL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEXA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF40A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTRF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TADA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEX264 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TERF2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SANT/Myb IPR001005 2.18
Category members Myb-like_dom IPR017877 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring TERF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 619 MRE11A-RAD50-NBN-TRF2 complex Database 1.09
Category members Corum 1220 TRF2-Ku complex Database 0.68
Category members Corum 1205 TRF2-Rap1 complex III Database 0.24
Category members Corum 1218 BLM-TRF2 complex Database 0.05
Category members Corum 1204 Rap1 complex Database 0.04
Category members Corum 1197 TRF1-TIN2 complex Database 0
Category members Corum 1198 TIN2 complex Database 0
Category members Corum 1206 TRF-Rap1 complex I, 2MD Database 0
Category members Corum 1207 TRF2-Rap1 complex II Database 0
Category members Corum 1217 WRN-TRF2 complex Database 0
Category members Corum 1221 TFIIA-TRF2 complex Database 0
Category members Corum 138 Telosome complex Database 0


Categories featuring TERF2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0030870 Mre11 complex Database 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0042162 telomeric DNA binding Database 1.23
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0003691 double-stranded telomeric DNA binding Database 0.62
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0032205 negative regulation of telomere maintenance Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members GO Category GO:0010834 telomere maintenance via telomere shortening Database 0.09
Category members GO Category GO:0016233 telomere capping Database 0
Category members GO Category GO:0031627 telomeric loop formation Database 0
Category members GO Category GO:0031848 protection from non-homologous end joining at telomere Database 0
Category members GO Category GO:0032206 positive regulation of telomere maintenance Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0070198 protein localization to chromosome, telomeric region Database 0


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