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Query: SYNE2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SYNE2 1 5.916 -2.100 3.290 0.830 0.623

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SYNE2 Phosphorylation S4108 1.388 _RGS(ph)MSYLAAVEEEVEESSVK_
SYNE2 Phosphorylation T6365 0.448 _LTSCTPGLEDEKEASENET(ph)DMEDPR_
SYNE2 Phosphorylation S6361 -0.215 -0.097 _LTSCTPGLEDEKEAS(ph)ENETDMEDPR_

Background Information for SYNE2:


Pubmed-SYNE2 »
Uniprot-SYNE2 »
Biogrid-SYNE2 »
ProteomicsDB-SYNE2 »

Tumorportal-SYNE2 »
COSMIC-SYNE2 »
GenomeRNAi-SYNE2 »
Genecards-SYNE2


Protein-protein Interactions for SYNE2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MORC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2B Cat. description Hein, Mann, Cell 2015
Category members IP bait S100A4 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait TBC1D16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPN6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEP170 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SYNE2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members KASH IPR012315 0.52
Category members CAMSAP_CH IPR022613 0.13
Category members Calpain_domain_III IPR022682 0


Protein complexes (CORUM database) featuring SYNE2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SYNE2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members Disease phenotype Autosomal_dominant_Emery-Dreifuss_muscular_dystrophy Autosomal dominant Emery-Dreifuss muscular dystrophy Database 0.89
Category members GO Category GO:0031527 filopodium membrane Database 0.74
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0031981 nuclear lumen Database 0.54
Category members GO Category GO:0006998 nuclear envelope organization Database 0.4
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0034993 SUN-KASH complex Database 0.28
Category members GO Category GO:0005640 nuclear outer membrane Database 0.18
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0031258 lamellipodium membrane Database 0.15
Category members GO Category GO:0007097 nuclear migration Database 0.14
Category members GO Category GO:0010761 fibroblast migration Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0030016 myofibril Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031022 nuclear migration along microfilament Database 0
Category members GO Category GO:0033017 sarcoplasmic reticulum membrane Database 0
Category members GO Category GO:0051642 centrosome localization Database 0


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