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Query: SRI

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRI 0 0.027 -0.540 1.260 -0.614 0.200 -0.437

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRI Ubiquitylation K127 -1.001 -0.186 _SGTVDPQELQK(gl)ALTTM(ox)GFR_
SRI Ubiquitylation K146 -0.939 -1.022 _LSPQAVNSIAK(gl)R_
SRI Ubiquitylation K68 -0.196 _CLTQSGIAGGYK(gl)PFNLETCR_

Background Information for SRI:


Pubmed-SRI »
Uniprot-SRI »
Biogrid-SRI »
ProteomicsDB-SRI »

Tumorportal-SRI »
COSMIC-SRI »
GenomeRNAi-SRI »
Genecards-SRI


Protein-protein Interactions for SRI
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ATXN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH14 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015


Protein Domains in SRI
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EF_hand_dom IPR002048 0


Protein complexes (CORUM database) featuring SRI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5371 Grancalcin-sorcin complex Database 0


Categories featuring SRI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0010649 regulation of cell communication by electrical coupling Database 0.23
Category members GO Category GO:0006942 regulation of striated muscle contraction Database 0.17
Category members GO Category GO:0042994 cytoplasmic sequestering of transcription factor Database 0.14
Category members GO Category GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0051924 regulation of calcium ion transport Database 0.11
Category members GO Category GO:0001508 regulation of action potential Database 0.05
Category members GO Category GO:0008016 regulation of heart contraction Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0031982 vesicle Database 0.01
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005246 calcium channel regulator activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0006880 intracellular sequestering of iron ion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0010459 negative regulation of heart rate Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0033017 sarcoplasmic reticulum membrane Database 0
Category members GO Category GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus Database 0
Category members GO Category GO:0042584 chromaffin granule membrane Database 0
Category members GO Category GO:0051281 positive regulation of release of sequestered calcium ion into cytosol Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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