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Query: SPTBN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPTBN1 3 7.533 -2.120 3.900 0.059 -0.418 -0.700 0.255 0.415

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPTBN1 Ubiquitylation K2269 1.563 1.748 _EAVCEVALDYK(gl)K_
SPTBN1 Ubiquitylation K2270 1.484 1.748 _EAVCEVALDYKK(gl)_
SPTBN1 Phosphorylation S2319 0.406 0.012 _HEVSASTQS(ph)TPASSR_
SPTBN1 Phosphorylation S2338 -0.151 _AQTLPTSVVTITS(ph)ESSPGK_
SPTBN1 Phosphorylation S2340 -0.260 -0.175 _AQTLPTSVVTITSES(ph)SPGKR_
SPTBN1 Phosphorylation T2335 -0.213 _AQTLPTSVVT(ph)ITSESSPGKR_
SPTBN1 Ubiquitylation K593 -1.044 -0.240 _GVNASAQK(gl)FATDGEGYKPCDPQVIR_
SPTBN1 Phosphorylation T2320 0.156 -0.264 _HEVSASTQST(ph)PASSR_
SPTBN1 Phosphorylation S2341 -0.329 -0.373 _AQTLPTSVVTITSESS(ph)PGK_
SPTBN1 Phosphorylation S2102 -0.534 -0.677 _RPPS(ph)PEPSTK_
SPTBN1 Ubiquitylation K2344 1.728 -0.691 _AQTLPTSVVTITSESSPGK(gl)R_
SPTBN1 Ubiquitylation K105 -0.685 _LPKPTK(gl)GR_
SPTBN1 Ubiquitylation K924 0.362 _QLMHSGHPSEK(gl)EIK_
SPTBN1 Ubiquitylation K1532 -0.807 _NQTLQK(gl)EIQGHQPR_
SPTBN1 Ubiquitylation K2177 0.394 _AK(gl)TALPAQSAATLPAR_
SPTBN1 Phosphorylation T2317 -0.391 _HEVSAST(ph)QSTPASSR_
SPTBN1 Ubiquitylation K2362 1.856 _FSLFGK(gl)K_
SPTBN1 Ubiquitylation K2363 1.856 _FSLFGK(gl)K_

Background Information for SPTBN1:


Pubmed-SPTBN1 »
Uniprot-SPTBN1 »
Biogrid-SPTBN1 »
ProteomicsDB-SPTBN1 »

Tumorportal-SPTBN1 »
COSMIC-SPTBN1 »
GenomeRNAi-SPTBN1 »
Genecards-SPTBN1


Protein-protein Interactions for SPTBN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ADD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ARRB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SEPT9 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015


Protein Domains in SPTBN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members PH_domain IPR001849 0.14
Category members CAMSAP_CH IPR022613 0.13
Category members Spectrin_bsu IPR016343 0.04
Category members PH_dom-spectrin-type IPR001605 0


Protein complexes (CORUM database) featuring SPTBN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPTBN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0008091 spectrin Database 0.43
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0043001 Golgi to plasma membrane protein transport Database 0.32
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0030863 cortical cytoskeleton Database 0.24
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members GO Category GO:0032437 cuticular plate Database 0.03
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1287 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 0 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0007009 plasma membrane organization Database 0
Category members GO Category GO:0007182 common-partner SMAD protein phosphorylation Database 0
Category members GO Category GO:0014731 spectrin-associated cytoskeleton Database 0
Category members GO Category GO:0030506 ankyrin binding Database 0
Category members GO Category GO:0030673 axolemma Database 0
Category members GO Category GO:0031430 M band Database 0
Category members GO Category GO:0051693 actin filament capping Database 0


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