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Query: SPG20

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPG20 0 0.974 0.600 -0.270

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPG20 Ubiquitylation K481 0.461 0.723 _GLYIAK(gl)QATGGAAK_
SPG20 Ubiquitylation K377 0.603 0.513 _QLDQGNK(gl)DVR_
SPG20 Ubiquitylation K447 0.472 0.432 _GAEITGK(gl)AIQK_
SPG20 Ubiquitylation K370 0.203 0.288 _TRPSSDQLKEASGTDVK(gl)QLDQGNK_
SPG20 Ubiquitylation K651 0.342 0.030 _ENQEGAANVNVRGEK(gl)DEQTK_
SPG20 Ubiquitylation K526 -0.110 0.007 _LVPESLK(gl)K_
SPG20 Ubiquitylation K515 0.330 -0.002 _ELAPHVKK(gl)_
SPG20 Ubiquitylation K514 -0.007 -0.114 _ELAPHVK(gl)K_
SPG20 Ubiquitylation K465 -0.598 -0.123 _IQPEEK(gl)PVEVSPAVTK_
SPG20 Phosphorylation S470 -0.392 _IQPEEKPVEVS(ph)PAVTK_
SPG20 Ubiquitylation K362 0.131 -0.424 _TRPSSDQLK(gl)EASGTDVK(gl)QLDQGNK_
SPG20 Ubiquitylation K475 -1.095 -1.020 _IQPEEKPVEVSPAVTK(gl)GLYIAK_
SPG20 Ubiquitylation K414 -1.501 -1.530 _DTSSEEVNLSHIVPCEPVPEEKPK(gl)_
SPG20 Ubiquitylation K47 0.528 _NYYK(gl)QGIGHLLR_
SPG20 Ubiquitylation K82 0.642 _MK(gl)ETLQNVR_
SPG20 Ubiquitylation K519 -0.213 _HGSK(gl)LVPESLKK_

Background Information for SPG20:


Pubmed-SPG20 »
Uniprot-SPG20 »
Biogrid-SPG20 »
ProteomicsDB-SPG20 »

Tumorportal-SPG20 »
COSMIC-SPG20 »
GenomeRNAi-SPG20 »
Genecards-SPG20


Protein-protein Interactions for SPG20
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP6R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SPG20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPG20
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members MIT IPR007330 0


Protein complexes (CORUM database) featuring SPG20
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPG20
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members GO Category GO:0051301 cell division Database 1.15
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0034389 lipid particle organization Database 0.28
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members Disease phenotype Autosomal_recessive_spastic_paraplegia_type_20 Autosomal recessive spastic paraplegia type 20 Database 0.11
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0009838 abscission Database 0
Category members GO Category GO:0030514 negative regulation of BMP signaling pathway Database 0
Category members GO Category GO:0050905 neuromuscular process Database 0
Category members GO Category GO:0060612 adipose tissue development Database 0


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