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Query: SPECC1L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPECC1L 1 -2.190 2.430 -1.240 -0.774 -0.472

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPECC1L Phosphorylation S384 0.662 0.715 _KGS(ph)SGNASEVSVACLTER_
SPECC1L Phosphorylation S832 0.196 -0.034 _RSS(ph)TSSEPTPTVK_
SPECC1L Phosphorylation S831 -0.105 _RS(ph)STSSEPTPTVK_
SPECC1L Ubiquitylation K939 -0.429 -1.893 _VPAMESAK(gl)TLSVSR_

Background Information for SPECC1L:


Pubmed-SPECC1L »
Uniprot-SPECC1L »
Biogrid-SPECC1L »
ProteomicsDB-SPECC1L »

Tumorportal-SPECC1L »
COSMIC-SPECC1L »
GenomeRNAi-SPECC1L »
Genecards-SPECC1L


Protein-protein Interactions for SPECC1L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANKRD26 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATMIN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRNA9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait G2E3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC30A6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPC25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPECC1L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CH-domain IPR001715 0.63
Category members bHLH_dom IPR011598 0.32
Category members CAMSAP_CH IPR022613 0.13


Protein complexes (CORUM database) featuring SPECC1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPECC1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0051301 cell division Database 1.15
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030835 negative regulation of actin filament depolymerization Database 0.4
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Disease phenotype Commissural_facial_cleft Commissural facial cleft Database 0
Category members GO Category GO:0005921 gap junction Database 0
Category members GO Category GO:0007026 negative regulation of microtubule depolymerization Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0


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