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Query: SPCS2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SPCS2 0 1.271 -0.420 0.000
SPCS2 0 1.271 -0.420 0.000 -0.022 0.483

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SPCS2 Ubiquitylation K38 0.883 _SGLLDK(gl)WK_
SPCS2 Ubiquitylation K169 0.808 _FDDK(gl)YTLK_
SPCS2 Ubiquitylation K57 0.447 _WDGSAVK(gl)NSLDDSAKK_
SPCS2 Ubiquitylation K71 0.408 _VLLEK(gl)YK_
SPCS2 Ubiquitylation K191 -0.072 0.376 _EAEFTK(gl)SIAK_

Background Information for SPCS2:


Pubmed-SPCS2 »
Uniprot-SPCS2 »
Biogrid-SPCS2 »
ProteomicsDB-SPCS2 »

Tumorportal-SPCS2 »
COSMIC-SPCS2 »
GenomeRNAi-SPCS2 »
Genecards-SPCS2


Protein-protein Interactions for SPCS2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SPCS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALPL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNASE1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MGAT4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NRN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRIG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SEC11C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TM2D3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOMM22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VNN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SPCS2
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SPCS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SPCS2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_731 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN 0 0
Category members Pathway Pathway_917 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION 0 0
Category members Pathway Pathway_918 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 0 0
Category members Pathway Pathway_919 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP 0 0
Category members GO Category GO:0005787 signal peptidase complex Database 0
Category members GO Category GO:0006465 signal peptide processing Database 0
Category members GO Category GO:0006508 proteolysis Database 0


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