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Query: SLX4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SLX4 0 1.480 -1.030 1.150 -0.112 0.152
SLX4 0 1.480 0.730 -0.910 -0.112 0.152

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SLX4 Phosphorylation S1070 0.448 _GGTSQVGS(ph)PTLLSPAVPSK_
SLX4 Phosphorylation S1469 0.326 0.010 _S(ph)PGLLDTTPIR_
SLX4 Phosphorylation S467 -0.153 _KKPPVS(ph)PPLLLVQDSETTGR_
SLX4 Phosphorylation S1028 -0.250 _LAPWQAS(ph)PPHPCR_
SLX4 Phosphorylation S1044 -1.068 _FLLGPPQGGS(ph)PR_
SLX4 Ubiquitylation K1179 0.849 -1.465 _SISSDPLEEK(gl)K_
SLX4 Ubiquitylation K1180 0.849 -1.465 _SISSDPLEEK(gl)K_
SLX4 Ubiquitylation K354 0.981 _TSHLK(gl)QCAVK_

Background Information for SLX4:


Pubmed-SLX4 »
Uniprot-SLX4 »
Biogrid-SLX4 »
ProteomicsDB-SLX4 »

Tumorportal-SLX4 »
COSMIC-SLX4 »
GenomeRNAi-SLX4 »
Genecards-SLX4


Protein-protein Interactions for SLX4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MUS81 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS Cat. description Hein, Mann, Cell 2015
Category members IP bait ERCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUS81 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SLX4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BTB/POZ-like IPR000210 0.43
Category members BTB/POZ_fold IPR011333 0.36
Category members BTB_POZ IPR013069 0.32


Protein complexes (CORUM database) featuring SLX4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SLX4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0008047 enzyme activator activity Database 0.15
Category members GO Category GO:0008821 crossover junction endodeoxyribonuclease activity Database 0.04
Category members GO Category GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing Database 0
Category members GO Category GO:0017108 5'-flap endonuclease activity Database 0
Category members GO Category GO:0033557 Slx1-Slx4 complex Database 0
Category members GO Category GO:0048257 3'-flap endonuclease activity Database 0


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