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Query: SLK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SLK 0 2.360 0.530 -0.730 0.497

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SLK Phosphorylation T569 0.771 0.828 _VDEDSAEDT(ph)QSNDGKEVVEVGQK_
SLK Ubiquitylation K246 0.555 _VLLK(gl)IAK_
SLK Phosphorylation Y195 0.182 0.287 _RDSFIGTPY(ph)WMAPEVVMCETSK_
SLK Phosphorylation S189 0.169 0.226 _RDS(ph)FIGTPYWM(ox)APEVVM(ox)CETSK_
SLK Phosphorylation T193 0.121 0.097 _RDSFIGT(ph)PYWMAPEVVM(ox)CETSK_
SLK Phosphorylation S571 0.209 -0.101 _VDEDSAEDTQS(ph)NDGKEVVEVGQK_
SLK Ubiquitylation K179 -0.345 _LADFGVSAK(gl)NTR_
SLK Ubiquitylation K1114 -0.291 _QFAAQEEK(gl)R_

Background Information for SLK:


Pubmed-SLK »
Uniprot-SLK »
Biogrid-SLK »
ProteomicsDB-SLK »

Tumorportal-SLK »
COSMIC-SLK »
GenomeRNAi-SLK »
Genecards-SLK


Protein-protein Interactions for SLK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SLK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PKK IPR022165 0.23
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring SLK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SLK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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