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Query: SLC1A3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SLC1A3 0 2.580 -1.000 1.770 -0.132 -0.393

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SLC1A3 Ubiquitylation K118 0.315 _ASGK(gl)MGMR_
SLC1A3 Ubiquitylation K30 0.754 0.240 _TLLAK(gl)KK_
SLC1A3 Phosphorylation S512 0.084 0.182 _DVEMGNS(ph)VIEENEMK_
SLC1A3 Ubiquitylation K521 -0.077 -0.672 _K(gl)PYQLIAQDNETEKPIDSETKM_
SLC1A3 Ubiquitylation K541 -0.417 -0.742 _KPYQLIAQDNETEKPIDSETK(gl)M_
SLC1A3 Ubiquitylation K10 -0.133 _SNGEEPK(gl)MGGR_

Background Information for SLC1A3:


Pubmed-SLC1A3 »
Uniprot-SLC1A3 »
Biogrid-SLC1A3 »
ProteomicsDB-SLC1A3 »

Tumorportal-SLC1A3 »
COSMIC-SLC1A3 »
GenomeRNAi-SLC1A3 »
Genecards-SLC1A3


Protein-protein Interactions for SLC1A3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDZK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SLC1A3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Na-dicarboxylate_symporter IPR001991 0


Protein complexes (CORUM database) featuring SLC1A3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SLC1A3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006811 ion transport Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_1271 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS 0 0.11
Category members GO Category GO:0016597 amino acid binding Database 0.11
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members GO Category GO:0048667 cell morphogenesis involved in neuron differentiation Database 0.07
Category members GO Category GO:0009416 response to light stimulus Database 0.06
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0006536 glutamate metabolic process Database 0.01
Category members Pathway Pathway_1207 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Disease phenotype ALTERNATING_HEMIPLEGIA_OF_CHILDHOOD ALTERNATING HEMIPLEGIA OF CHILDHOOD Database 0
Category members GO Category GO:0001504 neurotransmitter uptake Database 0
Category members GO Category GO:0005313 L-glutamate transmembrane transporter activity Database 0
Category members GO Category GO:0006537 glutamate biosynthetic process Database 0
Category members GO Category GO:0006835 dicarboxylic acid transport Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0009449 gamma-aminobutyric acid biosynthetic process Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0015813 L-glutamate transport Database 0
Category members GO Category GO:0016595 glutamate binding Database 0
Category members GO Category GO:0017153 sodium:dicarboxylate symporter activity Database 0
Category members GO Category GO:0021545 cranial nerve development Database 0
Category members GO Category GO:0031223 auditory behavior Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043205 fibril Database 0
Category members GO Category GO:0050806 positive regulation of synaptic transmission Database 0
Category members GO Category GO:0051938 L-glutamate import Database 0
Category members GO Category GO:0070779 D-aspartate import Database 0


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