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Query: SLC12A1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SLC12A1 1 2.641 0.800 -0.280
SLC12A1 1 2.641 0.800 -0.280 -0.386 -0.263

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SLC12A1 Ubiquitylation K958 1.077 1.080 _DVVVSVEYSK(gl)K_
SLC12A1 Ubiquitylation K959 1.579 1.080 _DVVVSVEYSKK(gl)_
SLC12A1 Ubiquitylation K409 0.293 0.878 _K(gl)QGASPLPQGAQSR_
SLC12A1 Ubiquitylation K841 -0.060 0.706 _EMSIDQAK(gl)YQR_
SLC12A1 Ubiquitylation K948 1.471 0.675 _SPGTK(gl)DVVVSVEYSK_
SLC12A1 Phosphorylation S944 0.525 _LKEGLDISHLQGQEELLSSQEKS(ph)PGTK_
SLC12A1 Ubiquitylation K833 0.031 0.510 _QAMK(gl)EMSIDQAK_
SLC12A1 Ubiquitylation K991 1.299 0.502 _TATQPLLK(gl)K_
SLC12A1 Ubiquitylation K280 -0.876 0.485 _DAVVTYTAESK(gl)GVVK_
SLC12A1 Ubiquitylation K995 1.109 0.084 _ESK(gl)GPIVPLNVADQK_
SLC12A1 Ubiquitylation K971 1.154 -0.324 _KSDLDTSKPLSEK(gl)PITHK_
SLC12A1 Phosphorylation S994 0.106 -0.409 _KES(ph)KGPIVPLNVADQK_
SLC12A1 Phosphorylation S79 -0.757 _DGGGVRDEGPAAAGDGLGRPLGPTPSQS(ph)R_
SLC12A1 Ubiquitylation K136 -0.018 _QTPADGEASGESEPAKGSEEAK(gl)GR_
SLC12A1 Ubiquitylation K284 -0.876 _DAVVTYTAESK(gl)GVVK_
SLC12A1 Ubiquitylation K966 1.102 _KSDLDTSK(gl)PLSEKPITHK_
SLC12A1 Ubiquitylation K983 0.798 _VEEEDGK(gl)TATQPLLKK_
SLC12A1 Ubiquitylation K992 1.045 _K(gl)ESKGPIVPLNVADQK_
SLC12A1 Ubiquitylation K1018 0.796 _LLEASTQFQKK(gl)_

Background Information for SLC12A1:


Pubmed-SLC12A1 »
Uniprot-SLC12A1 »
Biogrid-SLC12A1 »
ProteomicsDB-SLC12A1 »

Tumorportal-SLC12A1 »
COSMIC-SLC12A1 »
GenomeRNAi-SLC12A1 »
Genecards-SLC12A1


Protein-protein Interactions for SLC12A1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in SLC12A1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Na/K/Cl_cotranspt IPR002443 0.17
Category members Na/K/Cl_cotransptS IPR004842 0.09
Category members AA-permease/SLC12A_dom IPR004841 0.08
Category members AA_permease_N IPR013612 0


Protein complexes (CORUM database) featuring SLC12A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SLC12A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members GO Category GO:0006811 ion transport Database 0.18
Category members GO Category GO:0008511 sodium:potassium:chloride symporter activity Database 0.17
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0006813 potassium ion transport Database 0.11
Category members GO Category GO:0006814 sodium ion transport Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0007588 excretion Database 0.08
Category members GO Category GO:0048878 chemical homeostasis Database 0.04
Category members GO Category GO:0015377 cation:chloride symporter activity Database 0.03
Category members Pathway Pathway_1207 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES 0 0
Category members Disease phenotype Antenatal_Bartter_syndrome Antenatal Bartter syndrome Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0


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