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Query: SIRT6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIRT6 0 0.163 1.100 -1.060

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIRT6 Phosphorylation S303 0.071 0.092 _LEPKEES(ph)PTR_
SIRT6 Phosphorylation S10 -1.087 _(ac)SVNYAAGLS(ph)PYADK_
SIRT6 Phosphorylation T305 -0.259 _LEPKEES(ph)PTR_

Background Information for SIRT6:


Pubmed-SIRT6 »
Uniprot-SIRT6 »
Biogrid-SIRT6 »
ProteomicsDB-SIRT6 »

Tumorportal-SIRT6 »
COSMIC-SIRT6 »
GenomeRNAi-SIRT6 »
Genecards-SIRT6


Protein-protein Interactions for SIRT6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FTSJ1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait ROCK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TM9SF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait VANGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LOC554223 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIRT6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Sirtuin IPR003000 0
Category members Ssirtuin_cat_dom IPR026590 0
Category members DHS-like_NAD/FAD-binding_dom IPR029035 0


Protein complexes (CORUM database) featuring SIRT6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SIRT6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0070403 NAD+ binding Database 0.09
Category members GO Category GO:0010569 regulation of double-strand break repair via homologous recombination Database 0.01
Category members GO Category GO:0003950 NAD+ ADP-ribosyltransferase activity Database 0
Category members GO Category GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity Database 0
Category members GO Category GO:0005724 nuclear telomeric heterochromatin Database 0
Category members GO Category GO:0006471 protein ADP-ribosylation Database 0
Category members GO Category GO:0017136 NAD-dependent histone deacetylase activity Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0


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