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Query: SF3B2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SF3B2 1 3.203 0.230 0.340 0.157 -0.446 -0.060 -0.624 -0.234

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SF3B2 Phosphorylation S289 2.309 _QEEM(ox)NS(ph)QQEEEEMETDAR_
SF3B2 Phosphorylation S307 1.121 1.192 _SSLGQS(ph)ASETEEDTVSVSK_
SF3B2 Phosphorylation S309 0.696 0.852 _SSLGQSAS(ph)ETEEDTVSVSK_
SF3B2 Phosphorylation S302 0.747 0.772 _S(ph)SLGQSASETEEDTVSVSK_
SF3B2 Phosphorylation S303 0.747 0.772 _S(ph)SLGQSASETEEDTVSVSK_
SF3B2 Phosphorylation T780 -0.159 -0.706 _IEEAM(ox)DGSET(ph)PQLFTVLPEK_
SF3B2 Ubiquitylation K280 0.474 _ILQLK(gl)ESR_
SF3B2 Ubiquitylation K394 0.161 _IFEAFK(gl)LTDDVKK_
SF3B2 Ubiquitylation K492 0.640 _LLVHLK(gl)ATR_
SF3B2 Ubiquitylation K543 0.559 _EALQEK(gl)EEQK_
SF3B2 Ubiquitylation K547 0.271 _EALQEKEEQK(gl)TMK_
SF3B2 Ubiquitylation K563 0.609 _MGK(gl)IDIDYQK_
SF3B2 Phosphorylation S778 -0.295 _KKIEEAM(ox)DGS(ph)ETPQLFTVLPEK_

Background Information for SF3B2:


Pubmed-SF3B2 »
Uniprot-SF3B2 »
Biogrid-SF3B2 »
ProteomicsDB-SF3B2 »

Tumorportal-SF3B2 »
COSMIC-SF3B2 »
GenomeRNAi-SF3B2 »
Genecards-SF3B2


Protein-protein Interactions for SF3B2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP4M1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BATF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC132 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20B Cat. description Hein, Mann, Cell 2015
Category members IP bait MIS12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait NEIL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait TCEB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMM13 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC97 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZCRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZRSR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SF3B2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members PSP IPR006568 0


Protein complexes (CORUM database) featuring SF3B2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 2755 17S U2 snRNP Database 1.77
Category members Corum 430 18S U11/U12 snRNP Database 0.29
Category members Corum 1737 SF3b complex Database 0.08


Categories featuring SF3B2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005689 U12-type spliceosomal complex Database 0.29


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