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Query: SEC63

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SEC63 0 2.103 0.620 -0.720
SEC63 0 2.103 0.620 -0.720 0.490 0.453 0.473

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SEC63 Phosphorylation T537 0.944 _KKPT(ph)PVLLPQSK_
SEC63 Ubiquitylation K147 -0.616 0.359 _IAK(gl)AYAALTDEESR_
SEC63 Ubiquitylation K416 -0.090 _TIQDLVSLK(gl)ESDR_
SEC63 Ubiquitylation K287 -1.088 -0.189 _EIGSINLK(gl)K_
SEC63 Ubiquitylation K633 -0.387 _ALLETKSK(gl)_
SEC63 Ubiquitylation K300 -1.540 _NEPPLTCPYSLK(gl)AR_
SEC63 Ubiquitylation K631 -1.520 _ALLETK(gl)SK_

Background Information for SEC63:


Pubmed-SEC63 »
Uniprot-SEC63 »
Biogrid-SEC63 »
ProteomicsDB-SEC63 »

Tumorportal-SEC63 »
COSMIC-SEC63 »
GenomeRNAi-SEC63 »
Genecards-SEC63


Protein-protein Interactions for SEC63
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPRC5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YIPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SEC63
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Sec63-dom IPR004179 0.85
Category members DnaJ_domain IPR001623 0.3


Protein complexes (CORUM database) featuring SEC63
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SEC63
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0006620 posttranslational protein targeting to membrane Database 0.93
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0006612 protein targeting to membrane Database 0.29
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members Disease phenotype POLYCYSTIC_LIVER_DISEASE POLYCYSTIC LIVER DISEASE Database 0.21
Category members Disease phenotype Isolated_polycystic_liver_disease Isolated polycystic liver disease Database 0.01
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006807 nitrogen compound metabolic process Database 0
Category members GO Category GO:0010259 multicellular organismal aging Database 0


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