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Query: SEC61B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SEC61B 1 -2.351 -0.680 0.150 -3.497 -1.265 -1.434

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SEC61B Phosphorylation S49 1.434 2.261 _TTS(ph)AGTGGMWR_
SEC61B Phosphorylation S17 -0.477 -0.605 _PGPTPSGTNVGSSGRS(ph)PSK_
SEC61B Phosphorylation S14 -0.692 -0.695 _PGPTPSGTNVGSS(ph)GRSPSK_
SEC61B Phosphorylation T9 -0.867 _PGPTPSGT(ph)NVGSSGRSPSK_
SEC61B Phosphorylation S13 -0.477 -0.986 _PGPTPSGTNVGS(ph)SGRSPSK_
SEC61B Phosphorylation S7 -0.660 _PGPTPS(ph)GTNVGSSGRSPSK_

Background Information for SEC61B:


Pubmed-SEC61B »
Uniprot-SEC61B »
Biogrid-SEC61B »
ProteomicsDB-SEC61B »

Tumorportal-SEC61B »
COSMIC-SEC61B »
GenomeRNAi-SEC61B »
Genecards-SEC61B


Protein-protein Interactions for SEC61B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HAUS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait MED12 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015


Protein Domains in SEC61B
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SEC61B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5685 Membrane protein complex (VCP, UFD1L, SEC61B) Database 0


Categories featuring SEC61B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members GO Category GO:0000060 protein import into nucleus, translocation Database 0.42
Category members GO Category GO:0030433 ER-associated ubiquitin-dependent protein catabolic process Database 0.33
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members GO Category GO:0030970 retrograde protein transport, ER to cytosol Database 0.06
Category members GO Category GO:0031205 endoplasmic reticulum Sec complex Database 0.02
Category members GO Category GO:0048408 epidermal growth factor binding Database 0


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