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Query: SEC61A2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SEC61A2 2 11.096 1.160 -0.920 0.304 0.263

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SEC61A2 Ubiquitylation K394 1.586 _TWIEVSGSSAK(gl)DVAK_
SEC61A2 Phosphorylation S414 0.827 _ETS(ph)MVHELNR_
SEC61A2 Ubiquitylation K401 -1.030 0.553 _QLK(gl)EQQMVMR_
SEC61A2 Ubiquitylation K398 0.253 _DVAK(gl)QLK_
SEC61A2 Ubiquitylation K113 -0.118 _IIEVGDTPK(gl)DR_

Background Information for SEC61A2:


Pubmed-SEC61A2 »
Uniprot-SEC61A2 »
Biogrid-SEC61A2 »
ProteomicsDB-SEC61A2 »

Tumorportal-SEC61A2 »
COSMIC-SEC61A2 »
GenomeRNAi-SEC61A2 »
Genecards-SEC61A2


Protein-protein Interactions for SEC61A2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in SEC61A2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SecY/SEC61-alpha IPR002208 0.38
Category members Translocon_Sec61/SecY_plug_dom IPR019561 0.38
Category members SecY_su_dom IPR023201 0.38


Protein complexes (CORUM database) featuring SEC61A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SEC61A2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0008150 biological_process Database 0


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