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Query: SCIN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SCIN 0 0.497 -0.210 -0.400 0.401 -0.552 0.163

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SCIN Ubiquitylation K116 0.485 _ELQGYESNDFVSYFKGGLK(gl)_
SCIN Ubiquitylation K369 -1.683 _VAQIK(gl)QIPFDASK_

Background Information for SCIN:


Pubmed-SCIN »
Uniprot-SCIN »
Biogrid-SCIN »
ProteomicsDB-SCIN »

Tumorportal-SCIN »
COSMIC-SCIN »
GenomeRNAi-SCIN »
Genecards-SCIN


Protein-protein Interactions for SCIN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SCIN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Gelsolin-like_dom IPR007123 0.09
Category members Villin/Gelsolin IPR007122 0


Protein complexes (CORUM database) featuring SCIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SCIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045654 positive regulation of megakaryocyte differentiation Database 0.28
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members GO Category GO:0051014 actin filament severing Database 0.1
Category members GO Category GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0001786 phosphatidylserine binding Database 0
Category members GO Category GO:0005545 1-phosphatidylinositol binding Database 0
Category members GO Category GO:0017156 calcium ion-dependent exocytosis Database 0
Category members GO Category GO:0032330 regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0045010 actin nucleation Database 0
Category members GO Category GO:0051047 positive regulation of secretion Database 0
Category members GO Category GO:0051693 actin filament capping Database 0


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