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Query: RPL5

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RPL5 1 3.641 0.183 0.751
RPL5 1 3.641 0.077 -0.280 0.082

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RPL5 Ubiquitylation K27 0.560 1.718 _EGK(gl)TDYYAR_
RPL5 Ubiquitylation K221 0.554 1.466 _YLMEEDEDAYKK(gl)_
RPL5 Ubiquitylation K178 -0.152 1.436 _GAVDGGLSIPHSTK(gl)R_
RPL5 Ubiquitylation K158 -0.388 1.405 _TTTGNK(gl)VFGALK_
RPL5 Ubiquitylation K247 1.281 _NSVTPDMEEMYK(gl)K_
RPL5 Ubiquitylation K248 1.276 _NSVTPDMEEMYKK(gl)_
RPL5 Ubiquitylation K5 0.802 1.170 _GFVK(gl)VVK_
RPL5 Ubiquitylation K41 -0.434 0.969 _LVIQDK(gl)NK(gl)YNTPK_
RPL5 Ubiquitylation K255 -0.684 0.578 _ENPVYEK(gl)KPK_
RPL5 Ubiquitylation K43 -0.569 0.490 _LVIQDK(gl)NK(gl)YNTPK_
RPL5 Ubiquitylation K270 0.648 _WNRPK(gl)MSLAQK_
RPL5 Ubiquitylation K277 1.110 _MSLAQKK(gl)_

Background Information for RPL5:


Pubmed-RPL5 »
Uniprot-RPL5 »
Biogrid-RPL5 »
ProteomicsDB-RPL5 »

Tumorportal-RPL5 »
COSMIC-RPL5 »
GenomeRNAi-RPL5 »
Genecards-RPL5


Protein-protein Interactions for RPL5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2C Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CNBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FMR1NB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLTSCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGHMBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0020 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEB10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAK16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLEKHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SURF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF512 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF707 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZRSR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RPL5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ribosomal_L18/L5 IPR005484 0.28


Protein complexes (CORUM database) featuring RPL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 306 Ribosome, cytoplasmic Database INF
Category members Corum 308 60S ribosomal subunit, cytoplasmic Database INF


Categories featuring RPL5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_369 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 0 INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members Pathway Pathway_768 REACTOME_PEPTIDE_CHAIN_ELONGATION 0 INF
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_772 KEGG_RIBOSOME 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0003735 structural constituent of ribosome Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0006414 translational elongation Database INF
Category members GO Category GO:0006415 translational termination Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0019083 viral transcription Database INF
Category members GO Category GO:0022625 cytosolic large ribosomal subunit Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005840 ribosome Database 12.2
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members Disease phenotype Blackfan-Diamond_anemia Blackfan-Diamond anemia Database 2.38
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0042273 ribosomal large subunit biogenesis Database 0.59
Category members GO Category GO:0008097 5S rRNA binding Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32


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