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Query: RAPGEF6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAPGEF6 0 1.595 0.070 -0.270

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAPGEF6 Phosphorylation S1144 1.135 0.460 _RSS(ph)LLNAK_
RAPGEF6 Phosphorylation S1120 0.074 _SLS(ph)QGSTNSNM(ox)LDVQGGAHKK_
RAPGEF6 Phosphorylation S1544 -0.050 -0.196 _GLIVYCVTS(ph)PK_
RAPGEF6 Phosphorylation S1207 -1.222 -0.492 _SSEMS(ph)PVPMR_
RAPGEF6 Phosphorylation S280 -0.583 -0.664 _LPEGPVDS(ph)EDDEEEDEEIDRTDPLQGR_

Background Information for RAPGEF6:


Pubmed-RAPGEF6 »
Uniprot-RAPGEF6 »
Biogrid-RAPGEF6 »
ProteomicsDB-RAPGEF6 »

Tumorportal-RAPGEF6 »
COSMIC-RAPGEF6 »
GenomeRNAi-RAPGEF6 »
Genecards-RAPGEF6


Protein-protein Interactions for RAPGEF6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APBA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAPGEF6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members PDZ IPR001478 0.15
Category members Ras-assoc IPR000159 0
Category members cNMP-bd_dom IPR000595 0
Category members Ras-like_Gua-exchang_fac_N IPR000651 0
Category members RASGEF_cat_dom IPR001895 0
Category members cNMP-bd-like IPR018490 0
Category members Ras_GEF_dom IPR023578 0


Protein complexes (CORUM database) featuring RAPGEF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAPGEF6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0017016 Ras GTPase binding Database 1.28
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0030742 GTP-dependent protein binding Database 0
Category members GO Category GO:0043087 regulation of GTPase activity Database 0


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