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Query: RAP1GDS1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAP1GDS1 0 -3.286 -0.160 0.040 -0.805 -2.521

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for RAP1GDS1:


Pubmed-RAP1GDS1 »
Uniprot-RAP1GDS1 »
Biogrid-RAP1GDS1 »
ProteomicsDB-RAP1GDS1 »

Tumorportal-RAP1GDS1 »
COSMIC-RAP1GDS1 »
GenomeRNAi-RAP1GDS1 »
Genecards-RAP1GDS1


Protein-protein Interactions for RAP1GDS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait 6-Sep Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARL4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BAIAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DIRAS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IRGC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NKIRAS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAP1GDS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAP2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASL10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAP1GDS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Armadillo IPR000225 1.58
Category members ATPase_V1-cplx_hsu IPR004908 0


Protein complexes (CORUM database) featuring RAP1GDS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAP1GDS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain Database 0.08
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members GO Category GO:0005575 cellular_component Database 0
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0014829 vascular smooth muscle contraction Database 0
Category members GO Category GO:0015991 ATP hydrolysis coupled proton transport Database 0
Category members GO Category GO:0031034 myosin filament assembly Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0046961 proton-transporting ATPase activity, rotational mechanism Database 0


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