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Query: PYCR1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PYCR1 1 4.579 -1.990 3.890 -0.387 0.054 -0.369 0.817 0.574

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for PYCR1:


Pubmed-PYCR1 »
Uniprot-PYCR1 »
Biogrid-PYCR1 »
ProteomicsDB-PYCR1 »

Tumorportal-PYCR1 »
COSMIC-PYCR1 »
GenomeRNAi-PYCR1 »
Genecards-PYCR1


Protein-protein Interactions for PYCR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARMC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait PYCR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PYCR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 6-PGluconate_DH_C-like IPR008927 0.51
Category members Pyrroline-COOH_reductase IPR000304 0
Category members G3P_DH_NAD-dep_N IPR011128 0
Category members ProC_N IPR028939 0


Protein complexes (CORUM database) featuring PYCR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PYCR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_135 KEGG_ARGININE_AND_PROLINE_METABOLISM 0 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_394 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION 0 0
Category members Disease phenotype Geroderma_osteodysplastica Geroderma osteodysplastica Database 0
Category members GO Category GO:0004735 pyrroline-5-carboxylate reductase activity Database 0
Category members GO Category GO:0006561 proline biosynthetic process Database 0
Category members GO Category GO:0008652 cellular amino acid biosynthetic process Database 0
Category members GO Category GO:0034599 cellular response to oxidative stress Database 0
Category members GO Category GO:0046168 glycerol-3-phosphate catabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0055129 L-proline biosynthetic process Database 0


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