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Query: PRDX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRDX1 1 2.230 -0.560 -0.170 -0.180 -0.021 -0.352 0.472 -0.616

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRDX1 Ubiquitylation K35 1.615 _DISLSDYK(gl)GK_
PRDX1 Ubiquitylation K120 0.734 0.950 _TIAQDYGVLK(gl)ADEGISFR_
PRDX1 Ubiquitylation K37 -0.265 0.557 _DISLSDYKGK(gl)_
PRDX1 Ubiquitylation K7 -0.359 0.522 _(ac)SSGNAK(gl)IGHPAPNFK_
PRDX1 Ubiquitylation K197 1.482 0.519 _EYFSK(gl)QK_
PRDX1 Ubiquitylation K192 0.526 0.198 _SK(gl)EYFSK_
PRDX1 Ubiquitylation K136 0.736 0.002 _GLFIIDDK(gl)GILR_
PRDX1 Ubiquitylation K27 -0.787 _ATAVMPDGQFK(gl)DISLSDYK_
PRDX1 Ubiquitylation K109 -1.440 _KQGGLGPMNIPLVSDPK(gl)R_
PRDX1 Ubiquitylation K178 -0.223 _HGEVCPAGWK(gl)PGSDTIKPDVQK_

Background Information for PRDX1:


Pubmed-PRDX1 »
Uniprot-PRDX1 »
Biogrid-PRDX1 »
ProteomicsDB-PRDX1 »

Tumorportal-PRDX1 »
COSMIC-PRDX1 »
GenomeRNAi-PRDX1 »
Genecards-PRDX1


Protein-protein Interactions for PRDX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FERMT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRDX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB4B Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015


Protein Domains in PRDX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peroxiredoxin_C IPR019479 1.06
Category members Redoxin IPR013740 0.19
Category members Thioredoxin-like_fold IPR012336 0.16
Category members AhpC/TSA IPR000866 0.13


Protein complexes (CORUM database) featuring PRDX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRDX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051920 peroxiredoxin activity Database 0.94
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0000302 response to reactive oxygen species Database 0.35
Category members GO Category GO:0008379 thioredoxin peroxidase activity Database 0.35
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0005782 peroxisomal matrix Database 0.23
Category members GO Category GO:0005719 nuclear euchromatin Database 0.15
Category members GO Category GO:0032872 regulation of stress-activated MAPK cascade Database 0.11
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0016209 antioxidant activity Database 0.06
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0042267 natural killer cell mediated cytotoxicity Database 0.02
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0004601 peroxidase activity Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0019430 removal of superoxide radicals Database 0
Category members GO Category GO:0034101 erythrocyte homeostasis Database 0
Category members GO Category GO:0042345 regulation of NF-kappaB import into nucleus Database 0
Category members GO Category GO:0042744 hydrogen peroxide catabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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