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Query: PIK3C2B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIK3C2B 0 0.624 1.410 -1.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIK3C2B Ubiquitylation K90 0.041 0.583 _TDLK(gl)LLR_
PIK3C2B Ubiquitylation K476 0.231 _LQLMEQK(gl)VVR_
PIK3C2B Ubiquitylation K252 -0.155 _LNLK(gl)STYDAEMLR_

Background Information for PIK3C2B:


Pubmed-PIK3C2B »
Uniprot-PIK3C2B »
Biogrid-PIK3C2B »
ProteomicsDB-PIK3C2B »

Tumorportal-PIK3C2B »
COSMIC-PIK3C2B »
GenomeRNAi-PIK3C2B »
Genecards-PIK3C2B


Protein-protein Interactions for PIK3C2B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3YL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIK3C2B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members PI3/4_kinase_cat_dom IPR000403 1.52
Category members Phox IPR001683 0.24
Category members PI3K_Ras-bd_dom IPR000341 0.19
Category members PInositide-3_kin_accessory_dom IPR001263 0.13
Category members PI3K_C2_dom IPR002420 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members C2_dom IPR000008 0


Protein complexes (CORUM database) featuring PIK3C2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1185 EGFR-containing signaling complex Database 0


Categories featuring PIK3C2B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0035091 phosphatidylinositol binding Database 0.62
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046854 phosphatidylinositol phosphorylation Database 0.31
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity Database 0.19
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_102 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members GO Category GO:0001727 lipid kinase activity Database 0
Category members GO Category GO:0005942 phosphatidylinositol 3-kinase complex Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0016303 1-phosphatidylinositol-3-kinase activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0


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