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Query: PICK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PICK1 1 2.058 -1.350 3.270
PICK1 1 2.058 -1.350 3.270 0.038 0.092 0.062

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PICK1 Ubiquitylation K151 -1.211 -0.192 _AILCNDGLVK(gl)R_
PICK1 Ubiquitylation K164 -0.429 _TAELYK(gl)GMTEHTK_
PICK1 Ubiquitylation K219 -1.278 _SIEK(gl)FGIR_

Background Information for PICK1:


Pubmed-PICK1 »
Uniprot-PICK1 »
Biogrid-PICK1 »
ProteomicsDB-PICK1 »

Tumorportal-PICK1 »
COSMIC-PICK1 »
GenomeRNAi-PICK1 »
Genecards-PICK1


Protein-protein Interactions for PICK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PICK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PDZ IPR001478 0.15
Category members AH_dom IPR010504 0.05
Category members BAR_dom IPR004148 0


Protein complexes (CORUM database) featuring PICK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2272 PICK1-GRIP1-GLUR2 complex Database 0.04


Categories featuring PICK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway Database 0.36
Category members GO Category GO:0006605 protein targeting Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members Pathway Pathway_1155 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 0 0.13
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0006890 retrograde vesicle-mediated transport, Golgi to ER Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members GO Category GO:0002092 positive regulation of receptor internalization Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0015844 monoamine transport Database 0
Category members GO Category GO:0021782 glial cell development Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0036294 cellular response to decreased oxygen levels Database 0
Category members GO Category GO:0042149 cellular response to glucose starvation Database 0
Category members GO Category GO:0042734 presynaptic membrane Database 0
Category members GO Category GO:0043045 DNA methylation involved in embryo development Database 0
Category members GO Category GO:0043046 DNA methylation involved in gamete generation Database 0
Category members GO Category GO:0043113 receptor clustering Database 0
Category members GO Category GO:0045161 neuronal ion channel clustering Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0060292 long term synaptic depression Database 0


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