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Query: PI4KA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PI4KA 1 2.812 -1.320 2.600 -0.592 -0.340 -0.400 0.110
PI4KA 1 2.812 -0.070 -0.820 -0.592 -0.340 -0.400 0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PI4KA Phosphorylation S276 1.031 0.516 _TSS(ph)VSSISQVSPER_
PI4KA Phosphorylation S284 0.160 0.431 _TSSVSSISQVS(ph)PER_
PI4KA Ubiquitylation K1768 0.311 -0.424 _ITNVSAIIK(gl)PYPK_
PI4KA Phosphorylation S275 -0.044 -0.569 _KTS(ph)SVSSISQVSPER_
PI4KA Ubiquitylation K71 -0.660 _SLAVQRPASLEK(gl)VQK_
PI4KA Ubiquitylation K1074 -0.689 _ESIVK(gl)DFAAR_
PI4KA Ubiquitylation K484 -0.723 _LSEK(gl)LQSK_
PI4KA Ubiquitylation K124 -1.252 _LLK(gl)GLPK_
PI4KA Ubiquitylation K1819 -1.653 _SGTPMQSAAK(gl)APYLAK_
PI4KA Ubiquitylation K1152 -1.678 _QNTTLGATQLSERPACVK(gl)K_

Background Information for PI4KA:


Pubmed-PI4KA »
Uniprot-PI4KA »
Biogrid-PI4KA »
ProteomicsDB-PI4KA »

Tumorportal-PI4KA »
COSMIC-PI4KA »
GenomeRNAi-PI4KA »
Genecards-PI4KA


Protein-protein Interactions for PI4KA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MRPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM174A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPY2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PI4KA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RGS20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGOLN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PI4KA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members PI3/4_kinase_cat_dom IPR000403 1.52
Category members PInositide-3_kin_accessory_dom IPR001263 0.13
Category members Kinase-like_dom IPR011009 0.03


Protein complexes (CORUM database) featuring PI4KA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 725 P2X7 receptor signalling complex Database 0.53


Categories featuring PI4KA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0004430 1-phosphatidylinositol 4-kinase activity Database 0.68
Category members Pathway Pathway_501 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 0 0.46
Category members GO Category GO:0030660 Golgi-associated vesicle membrane Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046854 phosphatidylinositol phosphorylation Database 0.31
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members GO Category GO:0005798 Golgi-associated vesicle Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0


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