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Query: PI4K2A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PI4K2A 2 5.208 0.840 -0.110 0.942 0.288

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PI4K2A Phosphorylation S462 1.525 1.524 _SSS(ph)ESYTQSFQSR_
PI4K2A Phosphorylation S5 1.252 _(ac)MDETS(ph)PLVSPER_
PI4K2A Ubiquitylation K243 0.312 0.617 _VPK(gl)VGQR_
PI4K2A Ubiquitylation K141 0.012 0.109 _IYQGSSGSYFVK(gl)DPQGR_
PI4K2A Ubiquitylation K240 -0.760 0.024 _LALEK(gl)VPK_
PI4K2A Ubiquitylation K336 -0.688 -0.119 _DTDWVVVK(gl)EPVIK_
PI4K2A Phosphorylation S47 -0.349 -0.395 _VAAAAGSGPS(ph)PPGSPGHDR_
PI4K2A Phosphorylation S51 0.488 -0.461 _VAAAAGSGPS(ph)PPGS(ph)PGHDR_
PI4K2A Phosphorylation S460 1.154 _S(ph)SSESYTQSFQSR_

Background Information for PI4K2A:


Pubmed-PI4K2A »
Uniprot-PI4K2A »
Biogrid-PI4K2A »
ProteomicsDB-PI4K2A »

Tumorportal-PI4K2A »
COSMIC-PI4K2A »
GenomeRNAi-PI4K2A »
Genecards-PI4K2A


Protein-protein Interactions for PI4K2A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CNOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PHF8 Cat. description Hein, Mann, Cell 2015
Category members IP bait FANCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IRGC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIF3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBLAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM206 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM231 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PI4K2A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PI3/4_kinase_cat_dom IPR000403 1.52


Protein complexes (CORUM database) featuring PI4K2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PI4K2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0004430 1-phosphatidylinositol 4-kinase activity Database 0.68
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members Pathway Pathway_501 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 0 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_102 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 0 0
Category members Pathway Pathway_105 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031083 BLOC-1 complex Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0042734 presynaptic membrane Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0


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