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Query: PFKFB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFKFB2 0 2.362 -0.070 0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFKFB2 Phosphorylation S466 0.350 0.410 _RNS(ph)FTPLSSSNTIR_
PFKFB2 Phosphorylation T468 0.351 0.361 _RNSFT(ph)PLSSSNTIR_
PFKFB2 Phosphorylation S493 -0.264 -0.110 _NYSVGSRPLKPLS(ph)PLR_
PFKFB2 Ubiquitylation K305 1.201 _VWTSQLK(gl)R_

Background Information for PFKFB2:


Pubmed-PFKFB2 »
Uniprot-PFKFB2 »
Biogrid-PFKFB2 »
ProteomicsDB-PFKFB2 »

Tumorportal-PFKFB2 »
COSMIC-PFKFB2 »
GenomeRNAi-PFKFB2 »
Genecards-PFKFB2


Protein-protein Interactions for PFKFB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PFKFB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PFKFB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PFKFB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Chromatin_KTI12 IPR013641 0.09
Category members 6Pfruct_kin IPR003094 0.06
Category members Bifunct_6PFK/fruc_bisP_Ptase IPR016260 0.06
Category members His_Pase_superF_clade-1 IPR013078 0
Category members 6Phosfructo_kin IPR013079 0
Category members His_PPase_superfam IPR029033 0


Protein complexes (CORUM database) featuring PFKFB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PFKFB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0006000 fructose metabolic process Database 0.11
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members GO Category GO:0006089 lactate metabolic process Database 0.08
Category members GO Category GO:0032024 positive regulation of insulin secretion Database 0.07
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0006003 fructose 2,6-bisphosphate metabolic process Database 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members GO Category GO:0033133 positive regulation of glucokinase activity Database 0.04
Category members GO Category GO:0003873 6-phosphofructo-2-kinase activity Database 0
Category members GO Category GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity Database 0
Category members GO Category GO:0006007 glucose catabolic process Database 0


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