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Query: PFAS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFAS 1 3.711 2.630 -0.920 0.784 0.586 0.847

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFAS Phosphorylation S569 0.616 0.660 _S(ph)PNRDFLTHVSAR_
PFAS Ubiquitylation K279 0.218 _FCDNSSAIQGK(gl)EVR_
PFAS Ubiquitylation K494 -0.832 _GDPEMEQK(gl)MNR_

Background Information for PFAS:


Pubmed-PFAS »
Uniprot-PFAS »
Biogrid-PFAS »
ProteomicsDB-PFAS »

Tumorportal-PFAS »
COSMIC-PFAS »
GenomeRNAi-PFAS »
Genecards-PFAS


Protein-protein Interactions for PFAS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015


Protein Domains in PFAS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AIR_synth_C_dom IPR010918 0.03
Category members AIR_synth_N_dom IPR000728 0
Category members PurM_N-like IPR016188 0
Category members Class_I_gatase-like IPR029062 0


Protein complexes (CORUM database) featuring PFAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PFAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0006541 glutamine metabolic process Database 0.47
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_273 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0006189 'de novo' IMP biosynthetic process Database 0.13
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members GO Category GO:0009156 ribonucleoside monophosphate biosynthetic process Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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