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Query: PDE5A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDE5A 0 1.044 0.210 0.250

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDE5A Phosphorylation S86 0.392 0.402 _GHTESCSCPLQQS(ph)PR_

Background Information for PDE5A:


Pubmed-PDE5A »
Uniprot-PDE5A »
Biogrid-PDE5A »
ProteomicsDB-PDE5A »

Tumorportal-PDE5A »
COSMIC-PDE5A »
GenomeRNAi-PDE5A »
Genecards-PDE5A


Protein-protein Interactions for PDE5A
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in PDE5A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HD/PDEase_dom IPR003607 0.07
Category members PDEase_catalytic_dom IPR002073 0
Category members GAF IPR003018 0
Category members PDEase IPR023088 0
Category members GAF_dom_like IPR029016 0


Protein complexes (CORUM database) featuring PDE5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDE5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0046068 cGMP metabolic process Database 0.29
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0055118 negative regulation of cardiac muscle contraction Database 0.09
Category members GO Category GO:0060282 positive regulation of oocyte development Database 0.09
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0010613 positive regulation of cardiac muscle hypertrophy Database 0.04
Category members GO Category GO:0030553 cGMP binding Database 0.04
Category members Pathway Pathway_287 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 0 0
Category members Pathway Pathway_300 REACTOME_CGMP_EFFECTS 0 0
Category members GO Category GO:0004112 cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity Database 0
Category members GO Category GO:0005575 cellular_component Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009187 cyclic nucleotide metabolic process Database 0
Category members GO Category GO:0042130 negative regulation of T cell proliferation Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0046069 cGMP catabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity Database 0
Category members GO Category GO:0055119 relaxation of cardiac muscle Database 0


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