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Query: PCBP1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PCBP1 0 3.581 -0.900 0.950 -0.634 -0.728 -0.566

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PCBP1 Ubiquitylation K115 0.132 1.214 _LVVPATQCGSLIGK(gl)GGCK_
PCBP1 Ubiquitylation K32 0.838 0.772 _EVGSIIGKK(gl)_
PCBP1 Phosphorylation S173 0.607 0.607 _QICLVMLETLSQS(ph)PQGR_
PCBP1 Ubiquitylation K314 -0.244 0.190 _QM(ox)SGAQIK(gl)IANPVEGSSGR_
PCBP1 Phosphorylation S171 0.504 0.145 _QICLVMLETLS(ph)QSPQGR_
PCBP1 Phosphorylation S264 0.094 _QQSHFAM(ox)M(ox)HGGTGFAGIDSSS(ph)PEVK_
PCBP1 Ubiquitylation K31 -0.219 _EVGSIIGK(gl)KGESVK_
PCBP1 Ubiquitylation K351 0.034 -0.310 _LSSEK(gl)GMGCS_
PCBP1 Phosphorylation S189 -0.507 -0.654 _VMTIPYQPMPAS(ph)SPVICAGGQDR_
PCBP1 Phosphorylation S190 -0.743 -0.927 _VMTIPYQPMPASS(ph)PVICAGGQDR_

Background Information for PCBP1:


Pubmed-PCBP1 »
Uniprot-PCBP1 »
Biogrid-PCBP1 »
ProteomicsDB-PCBP1 »

Tumorportal-PCBP1 »
COSMIC-PCBP1 »
GenomeRNAi-PCBP1 »
Genecards-PCBP1


Protein-protein Interactions for PCBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PCBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETMAR Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PCBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members KH_dom_type_2 IPR004044 0.34
Category members KH_dom IPR004087 0.23
Category members KH_dom_type_1 IPR004088 0.13


Protein complexes (CORUM database) featuring PCBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PCBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14


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