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Query: PANX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PANX1 0 0.290 -0.440 -0.430

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PANX1 Ubiquitylation K381 0.720 _MDVVDGK(gl)TPMSAEMR_

Background Information for PANX1:


Pubmed-PANX1 »
Uniprot-PANX1 »
Biogrid-PANX1 »
ProteomicsDB-PANX1 »

Tumorportal-PANX1 »
COSMIC-PANX1 »
GenomeRNAi-PANX1 »
Genecards-PANX1


Protein-protein Interactions for PANX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF4A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMO Cat. description Hein, Mann, Cell 2015
Category members IP bait C4orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRPR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PANX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Innexin IPR000990 0


Protein complexes (CORUM database) featuring PANX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PANX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1204 REACTOME_THE_NLRP3_INFLAMMASOME 0 0.2
Category members GO Category GO:0050718 positive regulation of interleukin-1 beta secretion Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0032059 bleb Database 0.08
Category members GO Category GO:0005262 calcium channel activity Database 0.08
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0033198 response to ATP Database 0.04
Category members GO Category GO:0050717 positive regulation of interleukin-1 alpha secretion Database 0.04
Category members GO Category GO:0002931 response to ischemia Database 0.04
Category members GO Category GO:0050715 positive regulation of cytokine secretion Database 0.03
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005243 gap junction channel activity Database 0
Category members GO Category GO:0005921 gap junction Database 0
Category members GO Category GO:0006812 cation transport Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0015267 channel activity Database 0
Category members GO Category GO:0034214 protein hexamerization Database 0
Category members GO Category GO:0055077 gap junction hemi-channel activity Database 0


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