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Query: NUP98

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NUP98 0 3.828 0.500 -0.570 0.947 0.625 0.455

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NUP98 Phosphorylation S612 0.512 0.471 _NLNNSNLFS(ph)PVNR_
NUP98 Ubiquitylation K757 0.216 0.390 _ITNEK(gl)GECIVSDFTIGR_
NUP98 Phosphorylation S623 0.489 0.151 _DSENLAS(ph)PSEYPENGER_
NUP98 Phosphorylation S888 0.233 0.103 _YGLQDS(ph)DEEEEEHPSK_
NUP98 Phosphorylation T670 0.107 -0.276 _PIPQT(ph)PESAGNK_
NUP98 Phosphorylation S934 -0.774 -0.738 _PAPPPQSQS(ph)PEVEQLGR_
NUP98 Ubiquitylation K1019 -0.535 -1.181 _LPSK(gl)ADTSQEICSPR_
NUP98 Ubiquitylation K1608 0.191 -1.283 _ETFLTQK(gl)LR_
NUP98 Ubiquitylation K831 -1.112 _KAEVTLDGVWPTDK(gl)TSR_
NUP98 Ubiquitylation K1040 -0.003 _LPISASHSSK(gl)TR_
NUP98 Ubiquitylation K1341 0.428 _NSPVEAVFSYLTGK(gl)R_

Background Information for NUP98:


Pubmed-NUP98 »
Uniprot-NUP98 »
Biogrid-NUP98 »
ProteomicsDB-NUP98 »

Tumorportal-NUP98 »
COSMIC-NUP98 »
GenomeRNAi-NUP98 »
Genecards-NUP98


Protein-protein Interactions for NUP98
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUDT21 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP155 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP214 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PIM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEH1L Cat. description Hein, Mann, Cell 2015
Category members IP bait SSNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait XPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM136A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SEC13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPAST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NUP98
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring NUP98
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 87 Nup 107-160 subcomplex Database 1.16
Category members Corum 1347 NPC subcomplex (NUP98, NUP107, NUP133, NUP160) Database 1.15


Categories featuring NUP98
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members GO Category GO:0010827 regulation of glucose transport Database 5.83
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0008645 hexose transport Database 4.15
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0017056 structural constituent of nuclear pore Database 2.89
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0051292 nuclear pore complex assembly Database 2.26
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0015758 glucose transport Database 2.09
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0031080 nuclear pore outer ring Database 1.57
Category members GO Category GO:0044615 nuclear pore nuclear basket Database 1.35
Category members GO Category GO:0034399 nuclear periphery Database 1.34
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0006999 nuclear pore organization Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000059 protein import into nucleus, docking Database 0.29
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0042277 peptide binding Database 0


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