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Query: NUMA1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NUMA1 4 10.906 -0.500 0.260
NUMA1 4 10.906 -0.500 0.260 0.682 0.665 0.281
NUMA1 4 10.906 -0.500 0.260 1.086 -0.115 0.036 0.805 0.500

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NUMA1 Phosphorylation S401 2.552 2.428 _LSQLEEHLS(ph)QLQDNPPQEK_
NUMA1 Phosphorylation S706 2.397 _ALMTIIPDLS(ph)PNNPLSK_
NUMA1 Phosphorylation S82 2.155 _KHPS(ph)SPECLVSAQK_
NUMA1 Ubiquitylation K897 0.451 1.826 _ALQQVQEK(gl)EVR_
NUMA1 Phosphorylation S1231 0.725 1.160 _KNS(ph)LISSLEEEVSILNR_
NUMA1 Phosphorylation S1795 -0.386 1.025 _SQAPLESS(ph)LDSLGDVFLDSGR_
NUMA1 Phosphorylation S1794 0.156 0.929 _SQAPLES(ph)SLDSLGDVFLDSGRK_
NUMA1 Ubiquitylation K1517 0.737 0.662 _ELEVMTAK(gl)YEGAK_
NUMA1 Ubiquitylation K914 -0.138 0.483 _LADDLSTLQEK(gl)MAATSK_
NUMA1 Phosphorylation S1775 -0.770 0.419 _VES(ph)LESLYFTPIPAR_
NUMA1 Phosphorylation T1755 -0.222 _TQPDGT(ph)SVPGEPASPISQR_
NUMA1 Phosphorylation S1766 -0.247 _TQPDGTSVPGEPASPIS(ph)QR_
NUMA1 Phosphorylation S1763 0.155 -0.387 _TQPDGTSVPGEPAS(ph)PISQR_
NUMA1 Phosphorylation S1868 -0.414 -0.685 _LGS(ph)PDYGNSALLSLPGYRPTTR_
NUMA1 Phosphorylation S175 -0.787 -0.756 _APVPSTCSSTFPEELS(ph)PPSHQAK_
NUMA1 Phosphorylation T2006 -0.114 -1.359 _RVSLEPHQGPGT(ph)PESK_
NUMA1 Ubiquitylation K567 1.115 _HQVEQLSSSLK(gl)QK_
NUMA1 Ubiquitylation K569 1.115 _HQVEQLSSSLK(gl)QK_
NUMA1 Ubiquitylation K903 0.485 _AQK(gl)LADDLSTLQEK_
NUMA1 Ubiquitylation K920 -0.270 _MAATSK(gl)EVAR_
NUMA1 Ubiquitylation K945 -0.207 _ELVK(gl)EPAR_
NUMA1 Ubiquitylation K1144 -0.145 _LEQQCQK(gl)QQEQADSLER_
NUMA1 Ubiquitylation K1336 0.352 _AEELGQELK(gl)AWQEK_
NUMA1 Ubiquitylation K1481 0.696 _EK(gl)YVQELAAVR_
NUMA1 Ubiquitylation K1579 0.874 _LK(gl)AVQAQGGESQQEAQR_
NUMA1 Ubiquitylation K1671 1.528 _LGHELQQAGLK(gl)TK_
NUMA1 Ubiquitylation K1705 0.380 _DLGK(gl)FQVATDALK_
NUMA1 Ubiquitylation K1714 1.086 _FQVATDALK(gl)SR_
NUMA1 Phosphorylation S1756 0.224 _TQPDGTS(ph)VPGEPASPISQR_
NUMA1 Ubiquitylation K1828 0.570 _TTQIINITMTKK(gl)_

Background Information for NUMA1:


Pubmed-NUMA1 »
Uniprot-NUMA1 »
Biogrid-NUMA1 »
ProteomicsDB-NUMA1 »

Tumorportal-NUMA1 »
COSMIC-NUMA1 »
GenomeRNAi-NUMA1 »
Genecards-NUMA1


Protein-protein Interactions for NUMA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASPM Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRK Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPHOSPH8 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GPSM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCOC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NUMA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members tRNA-bd_arm IPR010978 0.08
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring NUMA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2966 NuMA-LGN-G-alpha-i-1 complex Database 0.06


Categories featuring NUMA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0005694 chromosome Database 3.87
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0000090 mitotic anaphase Database 0.47
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members GO Category GO:0005819 spindle Database 0.41
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Disease phenotype ACUTE_PROMYELOCYTIC_LEUKEMIA ACUTE PROMYELOCYTIC LEUKEMIA Database 0.39
Category members Pathway Pathway_1255 BIOCARTA_RANMS_PATHWAY 0 0.35
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0000132 establishment of mitotic spindle orientation Database 0.29
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0051321 meiotic cell cycle Database 0.23
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0006997 nucleus organization Database 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1252 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0060487 lung epithelial cell differentiation Database 0


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