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Query: NGLY1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NGLY1 0 1.481 0.750 -0.670

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NGLY1 Ubiquitylation K419 0.400 1.081 _DTINGLNK(gl)QR_
NGLY1 Ubiquitylation K406 0.017 0.444 _VK(gl)EALLR_
NGLY1 Ubiquitylation K204 -0.723 0.161 _ALACIPVQELK(gl)R_
NGLY1 Ubiquitylation K272 -0.873 -0.156 _SLLPSDDELK(gl)WGAK_
NGLY1 Ubiquitylation K100 0.078 _KASVEQLQK(gl)IR_

Background Information for NGLY1:


Pubmed-NGLY1 »
Uniprot-NGLY1 »
Biogrid-NGLY1 »
ProteomicsDB-NGLY1 »

Tumorportal-NGLY1 »
COSMIC-NGLY1 »
GenomeRNAi-NGLY1 »
Genecards-NGLY1


Protein-protein Interactions for NGLY1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait B4GALT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LINGO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAGPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD23B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NGLY1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Transglutaminase-like IPR002931 0.62
Category members Rad4/PNGase_transGLS-fold IPR018325 0.15
Category members PUG-dom IPR006567 0
Category members Galactose-bd-like IPR008979 0
Category members PUB_domain IPR018997 0


Protein complexes (CORUM database) featuring NGLY1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NGLY1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0006516 glycoprotein catabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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