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Query: NEFL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEFL 0 3.179 0.725 0.542
NEFL 0 3.179 0.894

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEFL Ubiquitylation K370 1.018 _YLK(gl)EYQDLLNVK_
NEFL Ubiquitylation K315 0.687 _AK(gl)TLEIEACR_
NEFL Ubiquitylation K281 0.548 _NMQNAEEWFK(gl)SR_
NEFL Ubiquitylation K271 0.227 _LAAK(gl)NMQNAEEWFK_
NEFL Ubiquitylation K293 -1.494 0.032 _FTVLTESAAK(gl)NTDAVR_
NEFL Ubiquitylation K267 -0.036 _AQYEK(gl)LAAK_
NEFL Ubiquitylation K157 -0.242 _LAAEDATNEK(gl)QALQGER_
NEFL Ubiquitylation K302 -0.315 _AAK(gl)DEVSESRR_
NEFL Ubiquitylation K91 -2.011 _TQEK(gl)AQLQDLNDR_

Background Information for NEFL:


Pubmed-NEFL »
Uniprot-NEFL »
Biogrid-NEFL »
ProteomicsDB-NEFL »

Tumorportal-NEFL »
COSMIC-NEFL »
GenomeRNAi-NEFL »
Genecards-NEFL


Protein-protein Interactions for NEFL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NEFH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEFL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEFM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSPRY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIM Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEFL
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring NEFL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NEFL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members Pathway Pathway_1168 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 0 0
Category members Pathway Pathway_1119 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 0 0
Category members Pathway Pathway_1169 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_935 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 0 0


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