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Query: NEDD8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEDD8 1 4.390 1.550 -1.140
NEDD8 1 4.390 1.550 -1.140 1.506 1.366 -0.201 -0.221
NEDD8 1 4.390 1.550 -1.140 0.333

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEDD8 Ubiquitylation K48 0.753 0.302 _LIYSGK(gl)QMNDEK_
NEDD8 Ubiquitylation K54 1.305 0.078 _QMNDEK(gl)TAADYK_
NEDD8 Ubiquitylation K11 0.414 _TLTGK(gl)EIEIDIEPTDKVER_
NEDD8 Ubiquitylation K22 0.364 _EIEIDIEPTDK(gl)VER_
NEDD8 Ubiquitylation K27 0.033 _IK(gl)ERVEEK_

Background Information for NEDD8:


Pubmed-NEDD8 »
Uniprot-NEDD8 »
Biogrid-NEDD8 »
ProteomicsDB-NEDD8 »

Tumorportal-NEDD8 »
COSMIC-NEDD8 »
GenomeRNAi-NEDD8 »
Genecards-NEDD8


Protein-protein Interactions for NEDD8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2M Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEDD8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rad60/SUMO_like IPR022617 1.93
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ubiquitin-like IPR000626 1.61
Category members Ubiquitin IPR019956 0.87


Protein complexes (CORUM database) featuring NEDD8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2188 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) Database 0.04


Categories featuring NEDD8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_973 BIOCARTA_P27_PATHWAY 0 0.1
Category members GO Category GO:0045116 protein neddylation Database 0.1
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0


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