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Query: NCLN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCLN 0 -0.937 0.271 0.229

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCLN Ubiquitylation K99 -1.283 -0.154 _LLDFSYEQYQK(gl)ALR_
NCLN Ubiquitylation K409 -1.875 -0.411 _VDSK(gl)TLTR_
NCLN Ubiquitylation K286 -1.603 -0.494 _FNYQGTK(gl)R_
NCLN Ubiquitylation K359 -1.739 -0.915 _FSMVHK(gl)R_

Background Information for NCLN:


Pubmed-NCLN »
Uniprot-NCLN »
Biogrid-NCLN »
ProteomicsDB-NCLN »

Tumorportal-NCLN »
COSMIC-NCLN »
GenomeRNAi-NCLN »
Genecards-NCLN


Protein-protein Interactions for NCLN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf85 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NCLN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_M28 IPR007484 0
Category members Nicastrin IPR008710 0


Protein complexes (CORUM database) featuring NCLN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NCLN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0


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