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Query: NAE1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NAE1 2 5.354 -2.100 3.690

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NAE1 Ubiquitylation K315 0.278 0.129 _ALK(gl)EFVAK_
NAE1 Ubiquitylation K12 1.535 -0.093 _LLKEQK(gl)YDR_
NAE1 Ubiquitylation K6 -0.713 _(ac)AQLGK(gl)LLK_
NAE1 Ubiquitylation K344 -0.043 -1.015 _YIK(gl)LQNVYR_
NAE1 Ubiquitylation K381 -1.445 _LLQSIGQAPESISEK(gl)ELK_
NAE1 Ubiquitylation K320 -1.602 _EFVAK(gl)EGQGNLPVR_
NAE1 Ubiquitylation K384 -1.021 -2.156 _LLQSIGQAPESISEKELK(gl)_

Background Information for NAE1:


Pubmed-NAE1 »
Uniprot-NAE1 »
Biogrid-NAE1 »
ProteomicsDB-NAE1 »

Tumorportal-NAE1 »
COSMIC-NAE1 »
GenomeRNAi-NAE1 »
Genecards-NAE1


Protein-protein Interactions for NAE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait UBE2M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NAE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ThiF_NAD_FAD-bd IPR000594 0.19
Category members Molybdenum_cofac_synth_MoeB IPR009036 0.19


Protein complexes (CORUM database) featuring NAE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2162 APPBP1-UBA3 complex Database 0.04


Categories featuring NAE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0045116 protein neddylation Database 0.1
Category members GO Category GO:0033314 mitotic DNA replication checkpoint Database 0.08
Category members GO Category GO:0019781 NEDD8 activating enzyme activity Database 0.04
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0


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