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Query: NACA

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NACA 0 0.153 -0.120 -0.230 0.387 -0.799 -0.094 -0.296

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NACA Phosphorylation T2024 0.225 -0.149 _VQGEAVSNIQENTQTPT(ph)VQEESEEEEVDETGVEVK_
NACA Phosphorylation S2029 -0.146 -0.296 _VQGEAVSNIQENTQTPTVQEES(ph)EEEEVDETGVEVK_
NACA Ubiquitylation K1941 0.879 _K(gl)AMSKLGLR_
NACA Ubiquitylation K1945 0.579 _AMSK(gl)LGLR_
NACA Ubiquitylation K1963 -0.781 _K(gl)SKNILFVITKPDVYK_
NACA Ubiquitylation K1976 -0.188 _NILFVITKPDVYK(gl)_
NACA Ubiquitylation K2005 0.209 _IEDLSQQAQLAAAEK(gl)FK_

Background Information for NACA:


Pubmed-NACA »
Uniprot-NACA »
Biogrid-NACA »
ProteomicsDB-NACA »

Tumorportal-NACA »
COSMIC-NACA »
GenomeRNAi-NACA »
Genecards-NACA


Protein-protein Interactions for NACA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015


Protein Domains in NACA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBA-like IPR009060 0.17
Category members Nas_poly-pep-assoc_cplx_dom IPR002715 0
Category members EGD2/NACA IPR016641 0


Protein complexes (CORUM database) featuring NACA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NACA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0017025 TBP-class protein binding Database 0.35
Category members GO Category GO:0048633 positive regulation of skeletal muscle tissue growth Database 0.26
Category members GO Category GO:0003231 cardiac ventricle development Database 0.05
Category members GO Category GO:0010664 negative regulation of striated muscle cell apoptotic process Database 0
Category members GO Category GO:0043403 skeletal muscle tissue regeneration Database 0
Category members GO Category GO:0048742 regulation of skeletal muscle fiber development Database 0
Category members GO Category GO:0061384 heart trabecula morphogenesis Database 0


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