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Query: MYL6

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYL6 0 2.716 -1.370 1.040 0.873 0.361 -0.268

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYL6 Ubiquitylation K119 -0.008 0.717 _TGDGK(gl)ILYSQCGDVMR_
MYL6 Ubiquitylation K174 -0.167 0.427 _NK(gl)DQGTYEDYVEGLR_
MYL6 Ubiquitylation K149 -0.380 -0.299 _VLGNPK(gl)SDEMNVK_
MYL6 Ubiquitylation K143 -0.749 -0.696 _ALGQNPTNAEVLK(gl)VLGNPK_

Background Information for MYL6:


Pubmed-MYL6 »
Uniprot-MYL6 »
Biogrid-MYL6 »
ProteomicsDB-MYL6 »

Tumorportal-MYL6 »
COSMIC-MYL6 »
GenomeRNAi-MYL6 »
Genecards-MYL6


Protein-protein Interactions for MYL6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait BOD1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1279 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH11 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL12A;MYL12B Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait SHCBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS28 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYL6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EF_hand_dom IPR002048 0


Protein complexes (CORUM database) featuring MYL6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 486 WIP-WASp-actin-myosin-IIa complex Database 0.31


Categories featuring MYL6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030898 actin-dependent ATPase activity Database 0.31
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0016461 unconventional myosin complex Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0


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