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Query: MTHFD1L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTHFD1L 0 -1.965 0.490 0.280 0.113 -0.190 -0.816 -0.058 0.299

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MTHFD1L Phosphorylation S358 -0.683 -0.630 _LQPLS(ph)PVPSDIEISR_

Background Information for MTHFD1L:


Pubmed-MTHFD1L »
Uniprot-MTHFD1L »
Biogrid-MTHFD1L »
ProteomicsDB-MTHFD1L »

Tumorportal-MTHFD1L »
COSMIC-MTHFD1L »
GenomeRNAi-MTHFD1L »
Genecards-MTHFD1L


Protein-protein Interactions for MTHFD1L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015


Protein Domains in MTHFD1L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Formate_THF_ligase IPR000559 0
Category members THF_DH/CycHdrlase IPR000672 0
Category members THF_DH/CycHdrlase_cat_dom IPR020630 0
Category members THF_DH/CycHdrlase_NAD-bd_dom IPR020631 0


Protein complexes (CORUM database) featuring MTHFD1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MTHFD1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0046653 tetrahydrofolate metabolic process Database 0.91
Category members GO Category GO:0015942 formate metabolic process Database 0.31
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0009396 folic acid-containing compound biosynthetic process Database 0.09
Category members Pathway Pathway_7 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM 0 0.08
Category members GO Category GO:0006760 folic acid-containing compound metabolic process Database 0.04
Category members GO Category GO:0004329 formate-tetrahydrofolate ligase activity Database 0
Category members GO Category GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0035999 tetrahydrofolate interconversion Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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