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Query: MLLT1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MLLT1 0 3.343 -0.550 1.140 0.694 0.478
MLLT1 0 3.343 1.060 -0.750 0.694 0.478

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MLLT1 Phosphorylation S475 1.258 _RS(ph)PESCSKPEK_
MLLT1 Phosphorylation S292 -0.227 -0.275 _RPATADS(ph)PKPSAK_
MLLT1 Phosphorylation S155 -0.447 _AGGVMVMPEGADTVSRPS(ph)PDYPMLPTIPLSAFSDPK_

Background Information for MLLT1:


Pubmed-MLLT1 »
Uniprot-MLLT1 »
Biogrid-MLLT1 »
ProteomicsDB-MLLT1 »

Tumorportal-MLLT1 »
COSMIC-MLLT1 »
GenomeRNAi-MLLT1 »
Genecards-MLLT1


Protein-protein Interactions for MLLT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C20orf114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DENND2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPB41L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RYBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MLLT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members YEATS IPR005033 0


Protein complexes (CORUM database) featuring MLLT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1252 EBAFa complex Database 2.5
Category members Corum 1239 EBAFb complex Database 1.57
Category members Corum 1457 AFF1-MLLT1-CBX8 complex Database 0.07


Categories featuring MLLT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0


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