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Query: MLF1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MLF1 0 -0.893 0.220 -0.290

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MLF1 Ubiquitylation K88 -0.584 -0.309 _NYMQK(gl)LER_

Background Information for MLF1:


Pubmed-MLF1 »
Uniprot-MLF1 »
Biogrid-MLF1 »
ProteomicsDB-MLF1 »

Tumorportal-MLF1 »
COSMIC-MLF1 »
GenomeRNAi-MLF1 »
Genecards-MLF1


Protein-protein Interactions for MLF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AARSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PROZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGAP1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSHR Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MLF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Myeloid_leukemia_factor IPR019376 0.29


Protein complexes (CORUM database) featuring MLF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MLF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0002318 myeloid progenitor cell differentiation Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0


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