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Query: METTL3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
METTL3 3 2.477 2.390 -1.450 -2.087 0.828 -0.203

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
METTL3 Phosphorylation S350 2.437 2.241 _DHTPS(ph)QELALTQSVGGDSSADR_
METTL3 Phosphorylation S43 0.351 -0.104 _NPEAALS(ph)PTFR_
METTL3 Ubiquitylation K459 -0.739 _VDEIIWVK(gl)TNQLQR_
METTL3 Ubiquitylation K513 -1.187 _STSHK(gl)PDEIYGMIER_

Background Information for METTL3:


Pubmed-METTL3 »
Uniprot-METTL3 »
Biogrid-METTL3 »
ProteomicsDB-METTL3 »

Tumorportal-METTL3 »
COSMIC-METTL3 »
GenomeRNAi-METTL3 »
Genecards-METTL3


Protein-protein Interactions for METTL3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait METTL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait ARNTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OLFM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in METTL3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members MT-A70-like IPR007757 0.02


Protein complexes (CORUM database) featuring METTL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring METTL3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0001510 RNA methylation Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Database 0


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