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Query: MAT2A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAT2A 0 -0.513 0.240 -0.710 -2.433 1.061 0.253 -0.678

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAT2A Ubiquitylation K307 -0.195 0.870 _SLVK(gl)GGLCR_
MAT2A Ubiquitylation K350 0.414 0.274 _ELLEIVK(gl)K_
MAT2A Ubiquitylation K81 0.110 0.137 _AAVDYQK(gl)VVR_
MAT2A Ubiquitylation K303 -0.265 _WVAK(gl)SLVK_
MAT2A Ubiquitylation K163 -0.321 _LNAK(gl)LAELRR_
MAT2A Ubiquitylation K228 -0.689 -0.376 _VIK(gl)AVVPAK_
MAT2A Ubiquitylation K289 -0.395 _DYTK(gl)VDR_
MAT2A Ubiquitylation K368 -0.719 _DLDLK(gl)KPIYQR_
MAT2A Ubiquitylation K367 -0.930 -1.508 _DLDLK(gl)KPIYQR_
MAT2A Ubiquitylation K234 -0.386 _AVVPAK(gl)YLDEDTIYHLQPSGR_
MAT2A Ubiquitylation K351 -0.735 _K(gl)NFDLRPGVIVR_

Background Information for MAT2A:


Pubmed-MAT2A »
Uniprot-MAT2A »
Biogrid-MAT2A »
ProteomicsDB-MAT2A »

Tumorportal-MAT2A »
COSMIC-MAT2A »
GenomeRNAi-MAT2A »
Genecards-MAT2A


Protein-protein Interactions for MAT2A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait IMMT Cat. description Hein, Mann, Cell 2015
Category members IP bait SEPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAT1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAT2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MAT2A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members S-AdoMet_synthetase IPR002133 0
Category members S-AdoMet_synt_N IPR022628 0
Category members S-AdoMet_synt_central IPR022629 0
Category members S-AdoMet_synt_C IPR022630 0
Category members S-AdoMet_synthetase_sfam IPR022636 0


Protein complexes (CORUM database) featuring MAT2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MAT2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0000096 sulfur amino acid metabolic process Database 0.15
Category members Pathway Pathway_400 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 0 0.04
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0
Category members Pathway Pathway_299 KEGG_SELENOAMINO_ACID_METABOLISM 0 0
Category members Pathway Pathway_399 REACTOME_SULFUR_AMINO_ACID_METABOLISM 0 0
Category members Pathway Pathway_82 REACTOME_PHASE_II_CONJUGATION 0 0
Category members Pathway Pathway_85 REACTOME_BIOLOGICAL_OXIDATIONS 0 0
Category members GO Category GO:0004478 methionine adenosyltransferase activity Database 0
Category members GO Category GO:0006556 S-adenosylmethionine biosynthetic process Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0006805 xenobiotic metabolic process Database 0
Category members GO Category GO:0032259 methylation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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